Head loss is the friction bill for moving water. It tells you how many feet of water column a pipe "eats" for every 100 feet of run - multiply by the real length and you have the pressure taxed out by friction alone.
Head Loss Calculator returns the Hazen-Williams friction loss per 100 ft along with the flowing velocity and the Reynolds number, so you can compare a 1/2 in line with a 3/4 in line before committing to either.